Structure, function, and diversity of class I major histocompatibility complex molecules.

INTRODUCTION ..................................................................................... 254 Class 1 MHC Polypeptides ...................................................................... 256 THE STRUCTURE OF HLA-A2 .................................................................. 257 Structural Overview .............................................................................. 257 Structure of the lg-like Domains ............................................................... 259 Structure of the c~I and e~e Domains .......................................................... 262 Size of Peptides that Fit in the Site ........................................................... 267 SEQUENCE DIVERSITY IN CLASS I HLA HEAVY CHAINS ........................... 268 The c~ Domain .................................................................................... 275 The c~1 and cee Domains ......................................................................... 275 ANTIGENIC PEPTIDE MOTIFS AND THE CONFORMATION OF BOUND PEPTIDES ..................................................................... 280 WHAT IS SEEN BY A TcR? ...................................................................... 281 A Model for How TcRs Bind to the Peptide-MHC omplex ............................. 282